Accession Number:

AD1051168

Title:

Targeting the CRMP2-Ca2+ Channel Complex for Abortive Treatment of Migraine and Posttraumatic Headache

Descriptive Note:

Technical Report,01 Sep 2016,31 Aug 2017

Corporate Author:

University of Arizona Tucson United States

Personal Author(s):

• Khanna, Rajesh
• Porreca,Frank
• Xie,Jennifer Y.
• Moutal,Aubin
• Eyde,Nathan

Report Date:

2017-09-01

Pagination or Media Count:

27.0

Abstract:

Migraine is one of the worlds most common neurological disorders. Current acute migraine treatments have sub-optimal efficacy and new therapeutic options are needed. Approaches targeting calcitonin gene related peptide CGRP signaling are clinically effective but small molecule antagonists have not been advanced due to toxicity. In this study, we explored the axonal growthspecification collapsin response mediator protein 2 CRMP2 as a novel druggable target for inhibiting CGRP release and for potential relevance for treatment of migraine pain and post-traumatic headache.

Descriptors:

• headache disorders
• pharmacology
• anticonvulsants
• pain
• neurons
• dura mater
• craniocerebral trauma
• electrophysiology
• biochemistry
• brain injuries
• therapy
• proteins

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE