Exaggerated Cap-Dependent Translation as a Mechanism for Corticostriatal Dysfunction in Fragile X Syndrome Model Mice
Technical Report,19 Oct 2016,18 Oct 2017
University of Lausanne LAUSANNE, VD Switzerland
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Our two laboratories Klann and Bagni - are committed to understanding the detailed molecular abnormalities associated with developmental disabilities and how these result in synaptic dysfunction and aberrant behavior. Our overall hypothesis is that repetitive and perseverative behaviors exhibited by FXS patients that can be recapitulated in the FXS model mice are caused by affected cortico-striatal synapses. To test this hypothesis, we propose two specific aims 1 To determine cortico-striatal synaptic composition, function and plasticity in FXS model mice 2 To determine whether altered cortico-striatal synaptic plasticity and repetitiveperseverative behaviors displayed by FXS model mice are reversed by novel cap dependent translation inhibitors.
- Medicine and Medical Research