Accession Number:

AD1051088

Title:

Understanding the Interaction of Peptides and Proteins with Abiotic Surfaces: Towards Water-Free Biologics

Descriptive Note:

Technical Report,04 Aug 2011,03 Nov 2017

Corporate Author:

University of Michigan - Ann Arbor Ann Arbor United States

Personal Author(s):

Report Date:

2018-02-03

Pagination or Media Count:

38.0

Abstract:

Here are the major goals presented in the original proposal Aim 1 Develop systematic understanding of abioticbiotic interfaces. We aim to understand, how the structure and activity of proteins and peptides immobilized on abiotic surfaces depends upon a the chemical and physical nature of the abiotic surface b the physicochemical properties of the protein or peptide and c the nature of the surrounding medium water, air or other hydromimetic molecules. Aim 2 Develop design rules for water-free biologics based on engineered abioticbiotic interfaces. Using knowledge gained from studies in Aim 1, we aim to a engineer peptides and proteins with enhanced ability to retain structure and function in the absence of bulk water, and b develop abiotic surfaces displaying hydromimetic functionality that stabilizes the native structure and function of biological molecules in extremely low humidity or water-free interfaces i.e. a surface-air interface that lacks bulk water and in air that is not humidified.

Subject Categories:

  • Biochemistry
  • Physical Chemistry
  • Biochemistry
  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE