A Novel Animal Model for Investigating the Neural Basis of Focal Dystonia
Technical Report,31 Aug 2016,30 Aug 2017
The Research Foundation State University of New York Stony Brook United States
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The overall goal of the project was to develop an animal model of the focal dystonia benign essential blepharospasm. Consistent with the widely held view that dystonia results from an interaction between a predisposing condition and an environmental trigger, we proposed to use 7 Hz deep brain stimulation of the basal ganglia as the predisposing condition and dry eye as an environmental trigger to model blepharospasm in rodents. This reporting year we demonstrated that 7 Hz is a critical frequency for basal ganglia activity to create the predisposing condition for the development of blepharospasm. In addition, we showed that basal ganglia modulation of the superior colliculus can produce the exaggerated trigeminal excitability typical of blepharospasm.
- Medicine and Medical Research
- Anatomy and Physiology