Accession Number:

AD1050793

Title:

Noninvasive Detection of AR-FL/AR-V7 as a Predictive Biomarker for Therapeutic Resistance in Men with Metastatic Castration-Resistant Prostate Cancer

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

Johns Hopkins University Baltimore United States

Personal Author(s):

Report Date:

2017-10-01

Pagination or Media Count:

61.0

Abstract:

Understanding primary and acquired resistance to abiraterone and enzalutamide, and developing analytically validated and clinically qualified predictive biomarkers, remains a critically important unmet medical need. We propose non-invasive detection of full-length androgen receptor AR-FL and the androgen receptor splice variant 7AR-V7 AR-FLAR-V7 as a predictive biomarker for therapeutic resistance in men with metastatic castration resistant prostate cancer.

Subject Categories:

  • Medicine and Medical Research
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE