Noninvasive Optical Monitoring of Spinal Cord Hemodynamics and Oxygenation after Acute Spinal Cord Injury
Technical Report,01 Sep 2016,31 Aug 2017
University of British Columbia Vancouver, BC Canada
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Our objectives in Year 1 are fully addressed. Simultaneous to obtaining institutional UBC and ACURO approvals, a comprehensive assessment on current NIRS technology advancements related to tissue hemodynamics monitoring was performed. That study helped us to design and develop our first NIRS system V1 required for monitoring spinal cord oxygenation and perfusion in our animal model of Experiment 1. We also identified available standard NIRS systems that were required to examine function and calibration of the V1 sensor. To monitor spinal cord cytochrome c redox state CCR, we designed a NIRS system prototype OXT5 that uses a novel multiwavelength hardware and algorithm. Intellectual Property IP protection of our developed systems and algorithms were initially assessed through UBC University Industrial Liaison Office UILO. We will follow up our UILO IP application after completion of Experiment 1. A pilot animal study with five pigs was conducted during the Y1-Q3 period to evaluate our NIRS sensors prototypes. The pilot study helped us to modify the protocol of Experiment 1 and refine some technical aspects of V1 and OXT5 NIRS sensors. We then started Experiment 1 as scheduled in Y1-Q4. Four animals are studied so far, and data collection and comparative analysis are under process. In year two we will complete Experiment 1 and focus on refining the technology to engineer a sensor that can be used in Experiment 2, a pig study with a seven-day post-injury survival period.
- Medicine and Medical Research
- Anatomy and Physiology
- Atomic and Molecular Physics and Spectroscopy