Engineer Synthetic Tumor Recruited Immunocellular Therapy (STRICT)
[Technical Report, Annual Report]
Massachusetts Institute of Technology
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The purpose of this project is to build a versatile Tumor Recruited Immunocellular Therapy STRICT system for prostate cancer. In the research period, we have validated that STRICT system have the potential to trigger robust immunotherapy. The majority of this validation is performed in an ovarian cancer model in vitro and in vivo. With ovarian cancer model, we have identified the key circuit component for building highly tumor-specific immunomodulatory system. We also identified the optimal circuit architecture for this system. In addition, we have created a library of sensors that can be used to detect multiple different cancer types. Currently, we are able to find new sensors for building this system toward treating prostate cancer. The next step forward is to validate whether combining the sensors with the optimal circuit architecture, the system remains highly specific to prostate cancer cells but not to other major tissue types in vitro. After the circuit specificity has been validated, we will identify the minimal percentage of tumor cells that need to be targeted by STRICT system to mediate in vivo efficacy. Furthermore, we will determine whether STRICT system can eliminate metastatic tumors via systemic delivery.
- Medicine and Medical Research