Accession Number:

AD1050398

Title:

Early Critical Care Decisions and Outcomes after SCI: Track-SCI

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

University of California, San Francisco

Personal Author(s):

Report Date:

2017-09-01

Pagination or Media Count:

40

Abstract:

Although there are established standards of care for acute SCI, these vary across trauma centers, and there are in fact very few evidence-based studies of SCI critical care to provide solid guidance for the many treatment decisions facing the SCI care team. In short, even the best teams do not know what the best practices are. We are in critical need of more information about the physiology of acute SCI, the variety of critical care treatments and strategies employed by different practitioners, and how these variables may relate to long-term functional outcomes and QoL, especially with respect to bladder and autonomic functions and their relationship to infection. Our objective is to provide a comprehensive prospective analysis of multiple variables in acute SCI impacting long-term outcomes. The three core hypotheses are 1. Multiple critical care variables will be predictive of both sensory-motor and autonomic outcomes, and infection susceptibility at 6 and 12 mos after SCI. 2. QuantitativeMRI of cord damage, and biomarkers of acute immune responses to injury will predict neurological outcomes at dischargeand at 6 and 12 mos. 3. Advanced analytics will yield novel predictors of outcome that will facilitate subsequent clinical trials.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]