Lung Cancer-Specific Circular RNAs as Biomarkers
[Technical Report, Annual Report]
University of Mississippi Medical Center
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The major goal of this application is to determine whether lung cancer cells differentially express circular RNAs such that these circular RNAs may serve as novel biomarkers for lung cancer diagnosis and prognosis. There are two Tasks in this application. First, we will perform microarray profiling to determine whether lung cancer cells display different patterns of circular RNAs from those of normal cells. Second, we will determine whether differential expression of circular RNAs can also be detected in cell culture models. Third, we will determine whether circular RNAs can be detected in circulation system. The success of this study may lead to novel clinical applications such as identification of biomarkers or therapeutic targets for lung cancer.
- Medicine and Medical Research