Therapeutic Sleep for Traumatic Brain Injury
Technical Report,01 Jun 2016,31 May 2017
Northwestern University Evanston United States
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This proposal will test the hypothesis that correcting sleep disorders can have a therapeutic effect on Traumatic Brain Injury TBI The majority of TBI patients develop sleep disorders, a correlation that is extremely prevalent in military personnel. Here, we have developed a paradigm to induce TBI in Drosophila. TBI induction results in increased mortality, impaired climbing behavior, decreasedfragmented sleep and cell death. We also discovered a biphasic response in both impaired climbing behavior and altered gene expression in glia cells. We are currently testing whether sleep induction can restore these impairments.
- Medicine and Medical Research
- Anatomy and Physiology
- Genetic Engineering and Molecular Biology