Accession Number:

AD1050214

Title:

Therapeutic Sleep for Traumatic Brain Injury

Descriptive Note:

Technical Report,01 Jun 2016,31 May 2017

Corporate Author:

Northwestern University Evanston United States

Personal Author(s):

Report Date:

2017-06-01

Pagination or Media Count:

8.0

Abstract:

This proposal will test the hypothesis that correcting sleep disorders can have a therapeutic effect on Traumatic Brain Injury TBI The majority of TBI patients develop sleep disorders, a correlation that is extremely prevalent in military personnel. Here, we have developed a paradigm to induce TBI in Drosophila. TBI induction results in increased mortality, impaired climbing behavior, decreasedfragmented sleep and cell death. We also discovered a biphasic response in both impaired climbing behavior and altered gene expression in glia cells. We are currently testing whether sleep induction can restore these impairments.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology
  • Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE