Accession Number:

AD1049937

Title:

Macrophage Efferocytosis and Prostate Cancer Bone Metastasis

Descriptive Note:

Technical Report,15 Sep 2014,14 Dec 2017

Corporate Author:

University of Michigan Ann Arbor United States

Personal Author(s):

• Sinder,Benjamin P.

Report Date:

2018-03-01

Pagination or Media Count:

44.0

Abstract:

Findings identify macrophages and efferocytosis as a key mediator of prostate cancer skeletal metastasis and the bone microenvironment. Specifically, phagocytic macrophages and efferocytosis were found to be upregulated in the blood of patients with metastatic prostate cancer. Moreover, inhibiting phagocytic macrophages with the chemotherapeutic trabectedin reduced efferocytosis and prostate cancer tumor size in murine models. In addition, trabectedin inhibition of macrophages significantly altered macrophages and efferocytosis in the bone microenvironment a common site of prostate cancer metastasis. Trabectedin was further found to reduce bone mass and bone healing.

Descriptors:

• Macrophages
• bone and bones
• prostate cancer
• neoplasms
• Metastasis
• inhibition
• chemotherapy

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE