Accession Number:

AD1049907

Title:

Branched Nerve Allografts to Improve Outcomes in Facial Composite Tissue Transplantation

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

Brigham and Womens Hospital

Personal Author(s):

Report Date:

2017-12-01

Pagination or Media Count:

35

Abstract:

The gold standard for peripheral nerve gap repair remains the autologous nerve graft. However, off-the-shelf alternatives are appealing due to additional graft material, shorter operative times and avoidance of donor site morbidity. This study aims to evaluate the functional and histologic recovery of a novel branched a cellular nerve allograft ANA in a complex nerve defect. Yucatan miniature swine n 13 underwent transection of the left inferior division of the facial nerve containing the marginal mandibular MMB and cervical C nerve branches. The gap was addressed either by a sural nerve autograft, ANA, or a human xenograft with or without oral Tacrolimus. Electrophysiologic assessments were performed pre-operatively and at the study endpoint 24 weeks to assess functional recovery using compound muscle action potential CMAP and histologic recovery by immunohistochemistry IHC using neurofilament and S100.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

[A, Approved For Public Release]