Accession Number:
AD1049907
Title:
Branched Nerve Allografts to Improve Outcomes in Facial Composite Tissue Transplantation
Descriptive Note:
[Technical Report, Final Report]
Corporate Author:
Brigham and Womens Hospital
Personal Author(s):
Report Date:
2017-12-01
Pagination or Media Count:
35
Abstract:
The gold standard for peripheral nerve gap repair remains the autologous nerve graft. However, off-the-shelf alternatives are appealing due to additional graft material, shorter operative times and avoidance of donor site morbidity. This study aims to evaluate the functional and histologic recovery of a novel branched a cellular nerve allograft ANA in a complex nerve defect. Yucatan miniature swine n 13 underwent transection of the left inferior division of the facial nerve containing the marginal mandibular MMB and cervical C nerve branches. The gap was addressed either by a sural nerve autograft, ANA, or a human xenograft with or without oral Tacrolimus. Electrophysiologic assessments were performed pre-operatively and at the study endpoint 24 weeks to assess functional recovery using compound muscle action potential CMAP and histologic recovery by immunohistochemistry IHC using neurofilament and S100.
Descriptors:
- health services
- peripheral nervous system
- autonomic nervous system
- surgery
- anatomy
- standards
- transplants
- body weight
- statistical analysis
- recovery
- tissues
- data science
- information science
- transplantation
- analysis of variance
- animals
- composite materials
- experimental design
- laboratory animals
- materials
Subject Categories:
- Anatomy and Physiology