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Development of a Novel Segmental Bone Defect Construct

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Technical Report,30 Sep 2016,29 Sep 2017

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Regents of the University of Idaho Moscow United States

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Bone tissue naturally regenerates itself upon injuries like a broken bone. However, when the size of the injury exceeds a threshold value this capability is lost and the injury is referred to as a critical size defect. When this occurs in a war fighter it requires the use of implant technology to either help maintain functionality or induce healing to return the individual to their natural state. However, there are a number of drawbacks to the existing technologies used for injury repair. These include slow healing times, scar tissue formation, and the possibility that the implant will be rejected by the body. Therefore there is interest in the development of new materials to foster the recovery of injured war fighters. The proposed work is focused on the development of such a material and it is targeted towards the segmental bone defect topic area in the FY14 PRMRP. In addition to cells, bone tissue is primarily composed of a calcium phosphate mineral referred to as hydroxyapatite, collagen, and other proteins which hold the first two components together. Many researchers have attempted to develop implant materials composed of hydroxyapatite, collagen, andor polymers with many formulations, but no one has been able to fully recreate the properties of natural bone. It is believed that one major missing component in the existing research is the lack of the other naturally occurring proteins, which are referred to as the SIBLING small integrin binding, N-linked glycoproteins family of proteins. It is believed that these proteins play a key role in natural bone because they are only found in hard tissues like bone and teeth, and all of the family members contain hydroxyapatite, collagen, and cell binding domains. In the proposed work, for the first time the SIBLING family of proteins will be combined with a new polymer material and their role in facilitating cell recruitment, proliferation, and bone production will be examined.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology
  • Biochemistry

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