Accession Number:

AD1048974

Title:

Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury

Descriptive Note:

Technical Report,27 Sep 2010,26 Sep 2014

Corporate Author:

Beth Israel Deaconess Medical Center Boston United States

Personal Author(s):

Report Date:

2014-12-01

Pagination or Media Count:

23.0

Abstract:

This work studied the ability to detect and characterize damage to spinal cord axons and myelin after spinal cord injury. Studies conducted at Beth Israel Deaconess Medical Center, the University of Pennsylvania and Drexel University produced promising results for assessing axon fiber diameter distributions in vivo. An initial focus on q-space imaging QSI was quantitatively successful in animal models and a STEAM based high b value approach was successfully implemented in human subjects. Direct myelin imaging was shown to be quantitatively reliable using ultra short TE UTE and zero TE ZTE methods in specimens. Myelin imaging in human subjects was implemented using inhomogeneous magnetization transfer ihMT methods. Overall, the results suggest that MR can detect and quantify these aspects of spinal cord damage after trauma.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE