Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury
Technical Report,27 Sep 2010,26 Sep 2014
Beth Israel Deaconess Medical Center Boston United States
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This work studied the ability to detect and characterize damage to spinal cord axons and myelin after spinal cord injury. Studies conducted at Beth Israel Deaconess Medical Center, the University of Pennsylvania and Drexel University produced promising results for assessing axon fiber diameter distributions in vivo. An initial focus on q-space imaging QSI was quantitatively successful in animal models and a STEAM based high b value approach was successfully implemented in human subjects. Direct myelin imaging was shown to be quantitatively reliable using ultra short TE UTE and zero TE ZTE methods in specimens. Myelin imaging in human subjects was implemented using inhomogeneous magnetization transfer ihMT methods. Overall, the results suggest that MR can detect and quantify these aspects of spinal cord damage after trauma.
- Medicine and Medical Research