Effect of Militarily-Relevant Metals on Muscle Wound Repair
Technical Report,30 Sep 2009,29 Sep 2010
Henry M. Jackson Foundation for the Advancement of Military Medicine Rockville United States
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The increased health concern over embedded metal fragments within DoD was highlighted by the release of Health Affairs Policy Letter 07-029 where a framework for follow-up care for those with embedded fragment injuries was outlined, as well as a list of nine metals of concern. An area not addressed was the potential effect of these metals on the repair of the muscle wounds that inevitably result from these types of injuries. To address this, we have used an in vitro model system of cultured muscle cells to determine if metals of interest to DoD adversely affect the ability of the cells to repair wound damage and, if so, can pharmacological intervention mitigate the adverse effects induced by metal exposure. We have found that several metals including nickel, lead, and antimony inhibit wound repair. Soluble forms of iron, as well as insoluble forms of cobalt, also inhibited repair. In many cases, repair capacity could be restored with a variety of pharmacological agents including antioxidants, metal chelators, and chemokines.
- Medicine and Medical Research