Molecular Innovations Toward Theranostics of Aggressive Prostate Cancer
Technical Report,01 Sep 2012,31 Aug 2017
Texas Christian Universtiy Fort Worth United States
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During the project, strategies for the preparation of new globular polymers dendrimers were introduced and methods for their rapid synthesis were pioneered. Both achievements address long-standing shortcomings of this field that have hindered translation to the clinic. Structure-activity relationships revealed design criteria for achieving high water solubility necessary for therapeutic application. Methods were surveyed for attaching varied functional groups including the therapeutic through biolabile or stablelinkages and imaging agent. This work led to the discovery of new hydrazone chemistry that offers broad application in druggene delivery. While the initially proposed multivalent therapeutics failed to recapitulate the activity of the lead compound, targeting prostate cancer cells with these constructs is now possible a 60x increase in selectivity is seen. In aggregate, this opens opportunities for realizing new treatments.
- Medicine and Medical Research