Accession Number:



Children's Hospital of Pittsburgh and Diabetes Institute of the Walter Reed Health Care System Genetic Screening in Diabetes: Candidate Gene Analysis for Diabetic Retinopathy

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

T.R.U.E. Research Foundaiton

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The hypothesis to be tested was that there are allelic variations of some genes that make the development of diabetes-related complications more likely in patients who carry them than those who do not. The 3 major complications to be evaluated were diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy. This was an observational study in which the investigators obtained DNA samples from the blood of patients with one or more of these complications and from as many their first-degree relatives as possible for testing in the laboratory of Dr. Massimo Trucco in the Rangos Research Center at the Childrens Hospital of Pittsburgh CHOP. Dr. Trucco is an internationally known immunologist and respected leader in genetic research in diabetes. He evaluated these samples by studying candidate genes selected a priori and testing for transmissiondisequilibrium a standard for analysis of linkage between a candidate gene and a specific disease.

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology

Distribution Statement:

[A, Approved For Public Release]