Accession Number:
AD1048533
Title:
Novel Models to Study Effect of High-Altitude Hypoxic Exposure and Placental Insufficiency on Fetal Oxygen Metabolism and Congenital Heart Defects
Descriptive Note:
Technical Report,30 Sep 2016,29 Sep 2017
Corporate Author:
University of Maryland, Baltimore Baltimore United States
Personal Author(s):
Report Date:
2017-10-01
Pagination or Media Count:
14.0
Abstract:
The idea for this proposal is that acute high altitude hypoxic exposure early in pregnancy during a critical period of organogenesis may critically reduce O2 transport to the fetus thereby causing Congenital Heart Defects in at-risk pregnancies. The first objective was to use a novel reporter of O2 concentrations, the ODDLuc mouse, to determine the dose-response relationship between hypoxia and reduced O2 delivery to the fetus. The second objective was to develop a novel mouse model of placental insufficiency to examine how maternal-fetal and gene-environment interactions may influence the effect of hypoxia on the developing heart.
Descriptors:
Subject Categories:
- Stress Physiology