Novel Models to Study Effect of High-Altitude Hypoxic Exposure and Placental Insufficiency on Fetal Oxygen Metabolism and Congenital Heart Defects
Technical Report,30 Sep 2016,29 Sep 2017
University of Maryland, Baltimore Baltimore United States
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The idea for this proposal is that acute high altitude hypoxic exposure early in pregnancy during a critical period of organogenesis may critically reduce O2 transport to the fetus thereby causing Congenital Heart Defects in at-risk pregnancies. The first objective was to use a novel reporter of O2 concentrations, the ODDLuc mouse, to determine the dose-response relationship between hypoxia and reduced O2 delivery to the fetus. The second objective was to develop a novel mouse model of placental insufficiency to examine how maternal-fetal and gene-environment interactions may influence the effect of hypoxia on the developing heart.
- Stress Physiology