Effects of Radiation on the Microbiota and Intestinal Inflammatory Disease
Technical Report,31 Aug 2016,30 Aug 2017
Cedar-Sinai Medical Center Los Angeles United States
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In this annual report covering initiating and collaborating PI projects we report the completion of experiments investigating the effect of inflammatory stimuli and focal irradiation of mice on the bacterial and fungal microbiota. We previously identified substantial changes in intestinal microbial communities induced by intestinal radiation exposure. Currently, we demonstrate that these changes correlate with increased sensitivity to inflammatory stimuli. As outlined in the project proposal, we are now in the midst of experiments aimed a evaluating the effects of radiation-induced changes in the microbiota on intestinal susceptibility to inflammatory disease.
- Medicine and Medical Research