Accession Number:



Children's Hospital of Pittsburgh and Diabetes Institute of the Walter Reed Health Care System Genetic Screening in Diabetes: Candidate Gene Analysis for Diabetic Retinopathy

Descriptive Note:

Technical Report,23 Apr 2007,22 Apr 2008

Corporate Author:

TRUE Research Foundation San Antonio United States

Personal Author(s):

Report Date:


Pagination or Media Count:



The hypothesis to be tested is that there are allelic variations of some genes that make the development of diabetes-related complications more likely in patients who carry them than those who do not. The 3 major complications to be evaluated are diabetic nephropathy, diabetic neuropathy, and diabetic retinopathy. This is an observational study in which the investigators will obtain DNA samples from the blood of patients with one or more of these complications and from as many their first-degree relatives as possible for testing in the laboratory of Dr. Massimo Trucco is an internationally known immunologist and respected leader in genetic research in diabetes. He will evaluate these samples by studying candidate genes selected a priori and testing for transmissiondisequilibrium a standard for analysis of linkage between a candidate gene and a specific disease.

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology

Distribution Statement: