Understanding and Controlling Living/Inorganic Interfaces to Enable Reconfigurable Switchable Materials
Technical Report,01 Oct 2015,30 Sep 2017
US Army Research Laboratory Aberdeen Proving Ground United States
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Results are highlighted for a 3-year study to study fundamental interactions between engineered E. coli cells and inorganic surfaces gold and functionalized silica to develop tailored, switchable bacterial adhesion to a target surface. This work includes protein engineering of multiple targets FimH and eCPX, a variety of analytical techniques including scanning electron microscopy and atomic force microscopy, theoretical models including multiphysics and multiscale treatments, as well as one of the first known studies of the role of environmental conditions and surface treatment on binding affinity.
- Inorganic Chemistry