Novel Autoantibody Serum and Cerebrospinal Fluid Biomarkers in Veterans with Gulf War Illness
Technical Report,30 Sep 2016,29 Sep 2017
Duke University Medical Center Durham United States
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The purpose of this project is to develop objective peripheral biomarkers for Gulf War Illness GWI. We planned to determine circulating autoantibodies to ten proteins associated with the central nervous system in sera and plasma from a group of 250 Gulf War veterans with Gulf War Illness GWI and from 200 controls 100 healthy GW controls, 100 disease controls. Preliminary results using Western blot assay showed increased levels of autoantibodies in GWI cases compared to chronic fatigue syndrome, irritable bowel syndrome and low back pain controls. These results confirm continuing presence of autoantibodies against neural proteins in GW veterans and are in agreement with recent reports indicating that 26 years after the war, the health of veterans with GWI is not improving.
- Medicine and Medical Research