A Rare Presentation of Hypercalcemia in a Patient with Urothelial Adenocarcinoma
59th MDW San Antonio United States
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Hypercalcemia is rare in urothelial cell carcinoma. When it does occur it typically is through a PTHrP-mediated process.Material and Methods A 58-year-old male presented with mental confusion, unsteady gait, and bladder distension due to hypercalcemia. Imaging showed recurrent urothelial adenocarcinoma confirmed by tissue biopsy and immunohistochemical staining. The etiology of this patients hypercalcemia was unclear as it did not fit the typical pattern of paraneoplastic hypercalcemia The patient had good response to supportive therapy but he continued to have acute episodes of hypercalcemia until his demise 5 months later. Conclusion Paraneoplastic hypercalcemia in urothelial adenocarcinoma is typically a PTHrP-mediated process although this case did not have a definitive etiology. It is important to be aware of this presentation and to suspect in a patient with supporting clinical symptoms.
- Medicine and Medical Research
- Anatomy and Physiology