Intravenous versus intramuscular cobinamide compared to intravenous saline (control) in the treatment of acute, survivable, hydrogen sulfide toxicity in swine (Sus Scrofa).
Technical Report,01 Sep 2014,31 Mar 2018
59th Medical Operations Squadron Lackland AFB United States
Pagination or Media Count:
Background Hydrogen sulfide H2S is one of the leading causes of unintentional workplace gas inhalation deaths. Significant exposures 50-400 ppm may produce difficulty in breathing, agitation, confusion, nausea and vomiting, elevated blood pressure and loss of consciousness. Several potential antidotes are available for hydrogen sulfide poisoning, but none have been completely successful. We previously reported that intravenous cobinamide successfully rescues severely NaHS-poisoned swine from apnea in the absence of assisted ventilation however, intramuscular administration is preferred in a workplace or mass casualty scenario.