Accession Number:

AD1048158

Title:

Hydroxocobalamin for Uncontrolled Hemorrhagic Shock Resuscitation in Swine (Sus scrofa)

Descriptive Note:

Technical Report,01 Jan 2015,31 Jan 2018

Corporate Author:

59th Medical Operations Squadron Lackland AFB United States

Report Date:

2018-01-02

Pagination or Media Count:

4.0

Abstract:

Background Traumatic hemorrhage is a leading cause of death in military environments and causes 50 of military deaths. Groin hemorrhage is lethal and not amenable to tourniquet application. Objectives To determine if HOC, a portable, safe and FDA approved drug, is effective in improving uncontrolled hemorrhagic shock and if it will improve systolic blood pressure in an uncontrolled hemorrhagic model without generating a rebleed with equal efficacy to Hextend registered trademark. Methods 16 animals anesthetized, instrumented. Femoral artery and vein were transected and allowed to bleed to sBP of 40mHg. Wound packed with QuickClot, 5 mins of manual pressure, and then randomly assigned to receive HOC or Hex. Observed for 2 hours. Results The groups did not significantly differ on post-treatment blood loss, total blood loss, post-bleed MAP, and end-of-study MAP or SVO2. At 60 and 120 minutes, the Hex group had significantly higher CO compared to the HOC group and the HOC group had significantly higher SVR compared to the Hex group. We speculate that these differences in CO and SVR can be attributed to the mechanism of HOC.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE