Central Mechanisms and Treatment of Blast-Induced Auditory and Vestibular Injuries
Technical Report,30 Dec 2016,29 Dec 2017
The Geneva Foundation Tacoma United States
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As a consequence of advances in military medical care there are greatly increased numbers of survivors of blast-induced traumatic brain injury bTBI sustaining persistent neurosensory dysfunction including hearing loss and balance disorder. The study is to utilize our well-defined shock tube simulation of mild blast-induced traumatic brain injury bTBI in rodents to characterize interrelated biomechanical and pathophysiological mechanisms of blast induced central auditory processing disorders CAPDs and central vestibular injuries CVIsand to develop an early therapeutic intervention for hearing loss and balance disorder mitigation. The major objectives of the proposed studies and relevant research sub-gaps are1 Verify the time course of hearing loss and balance disorders induced by blast exposure and define plasma and CSF TDP-43 as a biomarker related to blast-induced central auditoryvestibular deficits 2 Characterize blast induced biochemical, functional and morphological alterations in central auditoryvestibular systems and establish that blast induced altered expression of TDP-43 and its BDPs in these structures play a key pathophysiological mechanism leading to secondary injuries.
- Medicine and Medical Research