Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins
Technical Report,15 Aug 2013,14 Jul 2017
The University of British Columbia Vancouver, BC Canada
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In this project we have successfully produced recombinant VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSAinterferes with key functions of the cancer cell like growth, migration and invasion. We have furthermore made proof-of-concept that a VAR2CSA protein conjugated with a toxinhemiasterlin efficiently eradicates breast cancer bone metastasis in a syngeneic mouse model. As such, all aims in this project has been fulfilled.
- Medicine and Medical Research