Vitamin D Supplementation for Prevention of Post-Traumatic Osteoarthritis: Evaluation in Animal and Clinical Models
Technical Report,22 Sep 2016,21 Sep 2017
University of Chicago Medicine Chicago United States
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The purpose of this study is to evaluate the impact of Vitamin D in prevention and progression of post-traumatic osteoarthritis PTOA. The animal portion of this study involves surgical induction of osteoarthritis in mice, with supplementation of varying levels of Vitamin D, and evaluation using histology, immunohistochemistry, and micro-CT. The clinical portion is an add-on study at the United States Military Academy, evaluating a clinical cohort of USMA cadets treated for anterior cruciate ligament ACL tear, with pre- and post-injury serum 25-hydroxy-Vitamin D levels and correlation with joint space narrowing and biomarkers of cartilage injury. Findings from the animal model show preliminary evidence that Vitamin D supplementation may decrease OA in female animals, with histologic changes in animals given one of two supraphysiologic doses of oral Vitamin D. Micro-CT demonstrates greater osteophyte volume in females but no consistent correlation with supplementation level. In the clinical portion, we have enrolled 70100 70 of the required military cadets for the clinical study, but will evaluate serum 25-hydroxy-Vitamin D once the entire cohort is enrolled. Our findings provide preliminary support for the concept that Vitamin D supplementation could prevent the onset of often rapid joint destruction that occurs with PTOA, with important implications for high-risk military occupations.
- Anatomy and Physiology
- Medicine and Medical Research