Accession Number:
AD1047900
Title:
Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury
Descriptive Note:
Technical Report,15 Aug 2012,14 Aug 2015
Corporate Author:
University of Tennessee Health Science Center Memphis United States
Personal Author(s):
Report Date:
2018-02-01
Pagination or Media Count:
26.0
Abstract:
In year 3 of the Award we have extended our work to finalize the testing of Compound 49b in the IGBP-3 pathway in a trauma model. Specifically, we have done experimentation on how the inflammatory signaling pathway of TNF-alpha interacts with IGFBP-3 signaling in the blast model. As part of the PI transition, we extended our studies into the systemic effects of Compound 49b after ocular blast injury and successfully generated a method for the isolation of retinal ganglion cells, which are critical for the visual output from the eye to the brain in health and ocular injury.
Descriptors:
Subject Categories:
- Medicine and Medical Research
- Medicine and Medical Research