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Prevention of Organ Injury in Exertional Heat Stroke: Preclinical Evaluation of a New Class of NSAIDs

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Technical Report,30 Sep 2016,29 Sep 2017

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University of Florida Gainesville United States

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At the end of the 2nd year we have completed a greater than 128 adult male and female mice for metabolomics, physiological responses, lipidomics and hormonal analysis at 6 time points following exertional heat stroke. The results demonstrate a greater resistance to exertional heat stroke in female vs. male mice, with a greater than 1.5 fold increases in the capacity to perform work in the heat. Metabolomics in male mice demonstrated a conversion to higher beta oxidationof fatty acids in the heart mitochondria. There were few other differences between male and female mice in terms of metabolism, but all exhibited an energy crisis and conversion to lipid and protein metabolism. Female mice had altered metabolic hormonal profiles during recovery with significant elevations in corticosterone, resistin, insulin and glucagon. Plasma immune system cytokines were generally elevated in female vs. male mice but had a similar pattern over time. Only IL-5 and IL-9 were present in females but not males.

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  • Medicine and Medical Research

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