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The Role of an Aggrecan 32mer Fragment in Post-Traumatic Osteoarthritis

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Technical Report,30 Sep 2016,29 Sep 2017

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The University of Melbourne Dept of Pediatrics Parkville Australia

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During this reporting period we completed an 8 week DMM experiment, in the presence and absence of the AF-28 antibody. This experiment revealed a trend for an AF-28-mediated reduction in knee hyperalgesia, but not mechanical allodynia, in mice at 8 weeks post-surgery. This trend was not statistically significant, however, we are looking forward to results from the next time point, at 16 weeks post-surgery. The hind limbs from the 8 week study, from mice with and without AF-28 treatment, have been shipped to Australia and will now be analyzed for changes in cartilage, bone and synovial structure. In addition, we have made good progress on developing an AlphLISA immunoassay for detecting 32mer in sera, and we are not far away from final ethics approval to test sera in this new assay.

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  • Medicine and Medical Research

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