Accession Number:

AD1047652

Title:

Measuring Glial Metabolism in Repetitive Brain Trauma and Alzheimer's Disease

Descriptive Note:

Technical Report,15 Aug 2016,14 Aug 2017

Corporate Author:

Brigham and Womens Hospital Boston United States

Personal Author(s):

• Lin, Alexander

Report Date:

2017-09-01

Pagination or Media Count:

9.0

Abstract:

The overall aim of the study is to better understand glial metabolism within the context of RBT and AD and its potential findings in veterans. While the delay in the IRB approval has been frustrating, it has allowed for the resolution of a number of technical issues. The most significant finding in this report is the availability of 7 Tesla system for increased signal to noise ratio and greater spectral dispersion that allows for more accurate detection of dynamic glutamate changes after infusion of 13C-acetate that will be specific to glial cells. Combined with the previously described improvements utilizing denoising algorithms, there will be a significant improvement of data quality.

Descriptors:

• CRANIOCEREBRAL TRAUMA
• GLUTAMATES
• CHRONIC ENCEPHALOPATHY
• ALZHEIMER DISEASE
• Veterans (Military personnel)
• BRAIN INJURIES

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE