Accession Number:

AD1047642

Title:

Early Recognition of Chronic Traumatic Encephalopathy Through FDDNP PET Imaging

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

Cleveland Clinic Foundation Cleveland United States

Personal Author(s):

Report Date:

2017-10-01

Pagination or Media Count:

9.0

Abstract:

1. The PET biomarker, F-FDDNP 2-1-6-2-F-18fluoroethylmethylamino-2-naphthylethylidene malononitrile FDDNP has shown sensitivity for in vivo detection of tau in addition to -sheet-containing brain amyloid neuroaggregates. Tau protein in a characteristic distribution is felt to be the cardinal pathologic feature of Chronic Traumatic Encephalopathy. This project will examine whether FDDNP PET imaging correlates with, andor can predict, decline in cognitive function in those exposed to cumulative head trauma.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE