Accession Number:

AD1047631

Title:

Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

Albert Einstein College of Medicine Bronx United States

Personal Author(s):

Report Date:

2017-10-01

Pagination or Media Count:

16.0

Abstract:

From the completed analyses performed during the first year of the project, we have identified eleven SNPs that show an association with two-year toxicity following prostate cancer radiotherapy. Three of these single nucleotide polymorphisms SNPs meet the stringent threshold for genome-wide significance meta-p-value 5x10-8, and eight others approached genome-wide significance. For the three genome-wide significant SNPs, we found that the direction of the effect was consistent across all studies for which data were available.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE