Comprehensive Study of Acute Effects and Recovery After Concussion
Technical Report,30 Sep 2016,29 Sep 2017
Medical College of Wisconsin Milwaukee United States
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Utilizing a multi-dimensional research model, this study integrates biomechanical, clinical, neurobiological, and neuroradiological markers of mTBI, with the ultimate goal to more fully inform a neurobiopsychosocial model of mTBI risk, recovery and outcome. With the goal of baseline testing 900 athletes and enrolling 50 injured athletes and 50 contact and 50 non-contact controls over the course of 3 years, the project is progressing ahead of schedule and on budget. In the first 2.5 years of the study, we have enrolled 865 at baseline and accrued 86 concussed athletes in the multidimensional postinjury protocol, along with 99 non-injured control athletes. All groups are undergoing follow up evaluations within 6 hours of injury, 48 hours after injury, and 8, 15, and 45 days after injury. These evaluations include advanced brain neuroimaging, blood biospecimen collection, and clinical testing measures assessing balance, neurocognition, symptoms, and psychological health, which will be correlated with data from the Head Impact Telemetry system HITS. Several lines of preliminary analysis have been presented at national research meetings, submitted for publication or are in preparation for peer-review. Further data analyses are underway, with our investigative team developing advanced database platforms and analysis techniques.
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