Proteomic Analysis of Trauma-Induced Heterotopic Ossification Formation
Technical Report,30 Sep 2013,29 Sep 2017
Tulane University New Orleans United States
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This four-year Mentored IDEA proposal examined the proteome of serum samples derived from civilian and military orthopedic trauma patients and evaluated this information based on the occurrence of heterotopic ossification HO. Parallel studies of primary human stromalstem cells were examined in vitro to evaluate the underlying biochemical mechanism of HO formation. These outcomes implicated a number of pathways relating to the mTOR, collagen adhesion molecules, plasminogen, and the fosfra transcription factors as contributory to HO formation. These studies were extended to a rat blast injury model of HO which added confirmatory evidence in support of the human serum and stromalstem cell based findings. This information provides avenues for further exploration of HO pathophysiology.
- Medicine and Medical Research