Diffuse and Focal Brain Injury in a Large Animal Model of PTE: Mechanisms Underlying Epileptogenesis
Technical Report,30 Sep 2016,29 Sep 2017
Trustees of the University of Pennsylvania Philadelphia United States
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Military traumatic brain injury TBI is complex, often involving both diffuse and focal components. The contribution of each of these types of injury to epileptogenic brain activity and ultimately post traumatic epilepsy PTE is unclear, as are the mechanisms underlying this transition. Using a large animal model pig with adequate white matter pathways and a gyrencephalic brain, we are comparing these injury phenotypes and their potential contribution to PTE. After injury, we chronically implant high density electrodes in the hippocampus, above the cortex near the site of the focal contusion, and ECoG in the contralateral hemisphere. Pigs are monitored via video and electrophysiology up to nine months post injury, and blood biomarkers are being analyzed throughout in order to evaluate them as potential prognostic measures for the development of PTE. A full post-mortem neuropathological examination of axonal and neuronal injury will be performed to have circuitry changes, number and frequency of seizures and inter-ictal events correlated withthe neuropathological outcomes to determine the mechanistic underpinnings of PTE.
- Medicine and Medical Research