Biological Effects of Ionising Radiation and Countermeasures (Les effets biologiques des rayonnements ionisants et leurs contre-mesures)
NATO SCIENCE AND TECHNOLOGY ORGANIZATION NEUILLY-SUR-SEINE (FRANCE) NEUILLY-SUR-SEINE France
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The HFM-222 RTG active 2012 2016 addressed the medical challenges of NATO military defensive operations that could be conducted in a nuclearradiological NR environment. The HFM-222 Technical Report deals with high level and low level radiation issues through the following cross-cutting themes i biomarkers of exposure and effects ii early and late effects iii medical countermeasures iv modelling v guidance. Several deliverables taking into account military medical relevant research and operational needs were accomplished such as seventy peer reviewed publications and one exercise dealing with radiological triagediagnosis based on clinical dosimetry following a first biological dosimetry exercise implemented in 2011. The RTG produced different mature and deployable software tools dealing with the assessment triage i.e., Mobile-FRAT, which is an Android and IOS based application or the evaluation of Radiation Induced Performance Decrement RIPD and Health Effects from Nuclear and Radiological Environments HENRE which integrate complex exposure scenarios. Biomarkers of effect and damage were developed in order to diagnose and predict the clinical outcome of irradiated victims. Regarding treatment strategies, the RTG contributed to the FDA approval of granulocyte colony-stimulating factor filgrastim to mitigate radiation-induced neutropenia in NR accident victims. For high dose localized exposures adipose tissue-derived stem cells represent a promising cell drug to mitigate cutaneous radiation syndrome. Moreover, as low dose NR events may disrupt military operations, relevant models were developed to address related medical issues and retrospective epidemiological studies were conducted.
- Chemical, Biological and Radiological Warfare
- Radioactivity, Radioactive Wastes and Fission Products