Accession Number:

AD1047371

Title:

Diffusion MRI and the Detection of Alterations Following Traumatic Brain Injury

Descriptive Note:

Journal Article - Open Access

Corporate Author:

National Institutes of Health Bethesda United States

Report Date:

2017-06-13

Pagination or Media Count:

14.0

Abstract:

This article provides a review of brain tissue alterations that may be detectable using diffusion magnetic resonance imaging MRI dMRI approaches and an overview and perspective on the modern dMRI toolkits for characterizing alterations that follow traumatic brain injury TBI. Noninvasive imaging is a cornerstone of clinical treatment of TBI and has become increasingly used for preclinical and basic research studies. In particular, quantitative MRI methods have the potential to distinguish and evaluate the complex collection of neurobiological responses to TBI arising from pathology, neuroprotection, and recovery. dMRI provides unique information about the physical environment in tissue and can be used to probe physiological, architectural, and microstructural features. Although well-established approaches such as diffusion tensor imaging are known to be highly sensitive to changes in the tissue environment, more advanced dMRI techniques have been developed that may offer increased specificity or new information for describing abnormalities. These tools are promising, but incompletely understood in the context of TBI. Furthermore, model dependencies and relative limitations may impact the implementation of these approaches and the interpretation of abnormalities in their metrics. The objective of this paper is to present a basic review and comparison across dMRI methods as they pertain to the detection of the most commonly observed tissue and cellular alterations following TBI.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE