Restoring Function after Volumetric Muscle Loss: Extracellular Matrix Allograft or Minced Muscle Autograft
Technical Report,30 Sep 2016,29 Sep 2017
The Geneva Foundation Tacoma United States
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We propose a randomized surgical trial to restore muscle function following a severe muscle injury. A new surgical procedure using muscle autograft intends to restore functional muscle units. This new surgical method will be compared to the only other currently available surgical option for volumetric muscle loss VML, implantation of a porcine extra cellular matrix ECM scaffold, which has not conclusively been shown to be myogenic. The proposed surgical technique in this trial is a new surgical procedure using the patients own autograft muscle tissue from a large, uninjured muscle group. The autograft muscle will be minced and placed intramuscularly at the site of the VML. Prior small and large animal studies in our laboratory have demonstrated that minced muscle autograft MMA, by virtue of providing myogenic, angiogenic, neurogenic, and immune modulatory capacity to the injured area, results in regeneration of functional muscle units which integrate with underlying muscle mass. We hypothesize that minced muscle autograft MMA for the treatment of VML will yield greater restoration of muscle volume, greater improvement in validated functional measurements and self-reported outcomes, and greater myogenesis and single fiber strength compared to treatment with ECM.
- Medicine and Medical Research
- Anatomy and Physiology