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A Molecular Framework for Understanding DCIS

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Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

The Chancellor, Masters and Scholars of the University of Cambridge Cambridge United Kingdom

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This project centers on creating a molecular framework of DCIS ductal carcinoma in situ. DCIS is considered to be the precursor to Invasive Ductal Carcinoma IDC, the most common form of breast cancer. IDC accounts for 80 of all breast cancers, predominantly affecting women aged 55 and older however, at least a third of women with IDC are diagnosed before they reach 55.Not all patients with DCIS will develop IDC however, we are looking for ways to better predict those patients that need life-saving treatment, and separate these from those patients who are less at risk. So far we have made over 1300 RNA libraries and 410 whole genome libraries and dissected material from 115 freshly frozen patient biopsies. The tissue included for RNA and DNA analysis DCIS, IDC, stroma adjacent to DCISIDC and normal tissue.

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology

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