Accession Number:

AD1047306

Title:

Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis

Descriptive Note:

Technical Report,30 Sep 2016,29 Sep 2017

Corporate Author:

Tel Aviv University Tel Aviv-Jaffa Israel

Report Date:

2017-10-01

Pagination or Media Count:

56.0

Abstract:

During the three year of the award, our major research achievementsfindings were as followsi Farnesylthiosalicylic acid FTS therapy, a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis AIAmodel by all clinical and laboratory outcome parameters. ii Therapy with FTS as an add-onto the drug methotrexate MTX provides a superior protective effect compared to monotherapy.iii In the AIA model the FTS derivative, F-FTS, showed higher therapeutic efficacy compared to FTS. iv The functional genomics studies showed that FTS therapy inhibits the in vivoTH17 immune response.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE