Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis
Technical Report,30 Sep 2016,29 Sep 2017
Tel Aviv University Tel Aviv-Jaffa Israel
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During the three year of the award, our major research achievementsfindings were as followsi Farnesylthiosalicylic acid FTS therapy, a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis AIAmodel by all clinical and laboratory outcome parameters. ii Therapy with FTS as an add-onto the drug methotrexate MTX provides a superior protective effect compared to monotherapy.iii In the AIA model the FTS derivative, F-FTS, showed higher therapeutic efficacy compared to FTS. iv The functional genomics studies showed that FTS therapy inhibits the in vivoTH17 immune response.
- Medicine and Medical Research