Accession Number:

AD1047262

Title:

Maternal Brain Reactive Antibodies and Autism Spectrum Disorder

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

The Feinstein Institute for Medical Research Manhasset United States

Personal Author(s):

Report Date:

2016-10-01

Pagination or Media Count:

21.0

Abstract:

We have determined that one monoclonal antibody cloned from the memory B cell population of the mother of a child with ASD binds Caspr2. This antibody disrupts fetal brain development and leads to an ASD-like phenotype in the offspring. Forty percent of women with brain-reactive serology and a child with ASD exhibit antibodies to Caspr2 thus this antibody may contribute to approximately 5 percent of cases of ASD.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE