Maternal Brain Reactive Antibodies and Autism Spectrum Disorder
Technical Report,30 Sep 2015,29 Sep 2016
The Feinstein Institute for Medical Research Manhasset United States
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We have determined that one monoclonal antibody cloned from the memory B cell population of the mother of a child with ASD binds Caspr2. This antibody disrupts fetal brain development and leads to an ASD-like phenotype in the offspring. Forty percent of women with brain-reactive serology and a child with ASD exhibit antibodies to Caspr2 thus this antibody may contribute to approximately 5 percent of cases of ASD.
- Medicine and Medical Research