Targeting Premalignant Lesions - Implications for Early Breast Cancer Detection and Intervention
Technical Report,01 Apr 2016,31 Mar 2017
Sanford Burnham Prebys Medical Discovery Institute La Jolla United States
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Breast cancer progression constitutes a multistep process through a series of intermediate hyperplastic and neoplastic stages to invasive carcinoma. In this study, we aimed to identify peptides that specifically recognize premalignant lesions in the mammary tissue. To achieve this goal, we utilized the power of phage display to probe hyperplastic lesions associated with premalignant disease in a transgenic MMTV-PyMT animal model. We have identified a peptide CISQ that targets to the stroma in premalignant lesions and binds to cancer-associated fibroblasts CAFs in MMTV-PyMT mice. Considerable numbers of CAFs are frequently observed within the tumor-associated stroma of various human cancers, including those of the breast, prostate, lung, colon and pancreas and have been also reported in the premalignant lesions. This peptide could provide us with an opportunity to therapeutically intervene to successfully inhibit or even reverse tumor progression.
- Medicine and Medical Research