Blood Biomarker Profile of TBI-Associated Cognitive Impairment Among Old and Young Veterans
Technical Report,30 Sep 2016,29 Sep 2017
Northern California Institute for Research and Education San Francisco United States
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The goal of this project is to define the biomarker profile of TBI-associated cognitive impairment CI in veterans and compare it to that of veterans with Alzheimers Disease AD and to age-matched controls. Our overall hypothesis is that TBI-associated CI involves a unique biomarker profile that has features distinguishable from AD and normal aging. Specifically, we hypothesize that 1 patients with TBI associated CI will have higher phospho-tautotal tau ratio than controls who have not had a TBI, and that 2 TBI-associated CI will be associated with elevations in inflammatory markers compared to controls and 3 a decrease in b-amyloid measures compared to controls but not as low as in the setting of AD. We recently completed enrollment. Data from 160 participants has been collected 66 TBI, 54 controls, and 40 with AD and no TBI. Now that data collection is complete, we will examine the biomarker profile of the groups. This study will refine our understanding of the underlying mechanisms in TBI-associated CI, help predict who is at greatest risk of developing CI in veterans with TBI, and identify who may benefit from interventions and treatment for CI and its prevention.
- Medicine and Medical Research