Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis
Technical Report,30 Sep 2015,29 Sep 2016
Tel Aviv University Tel Aviv Israel
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During the first two year of the award, we made several high impact key observationsI Prophylactic treatment with Farnesylthiosalicylic acid FTS, a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis AIA model by all outcome parametersClinical assessment and relevant laboratoryimmunologicalMolecular analyses. II Prophylactic dosing of FTS combined with methotrexate MTX provides a synergistic protective effect 90 disease inhibition.III The FTS derivative, F-FTS, showed superior therapeutic clinical efficacy compared to FTS in the AIA model.
- Medicine and Medical Research