Accession Number:

AD1047106

Title:

Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

Tel Aviv University Tel Aviv Israel

Report Date:

2016-10-01

Pagination or Media Count:

37.0

Abstract:

During the first two year of the award, we made several high impact key observationsI Prophylactic treatment with Farnesylthiosalicylic acid FTS, a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis AIA model by all outcome parametersClinical assessment and relevant laboratoryimmunologicalMolecular analyses. II Prophylactic dosing of FTS combined with methotrexate MTX provides a synergistic protective effect 90 disease inhibition.III The FTS derivative, F-FTS, showed superior therapeutic clinical efficacy compared to FTS in the AIA model.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE