Macrophage Polarization and Utility of in Vivo Therapy with a Brain-Permeable Anti-TNF Agent in Models of Autism
Technical Report,30 Sep 2016,29 Sep 2017
Emory University Atlanta United States
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Human studies and animal models suggest that maternal immune activation MIA can have lasting effects on the offsprings neurodevelopment, immune set points, and behavior. The overall goal of this proposal is to define relevant signaling pathways and identify molecular targets and developmental windows for intervention and treatment. During this period, we ordered and expanded the TNFR1R2 DKO mice from Jackson labs on site. The mice are breeding and we plan to colonize them with stool of the Taconic C57Bl6N mice so that they will be responsive to the viral mimetic we plan to use. We began work on Aim 4 because it did not involve use of transgenic mouse colonies and pharmacological studies are underway to interrogate the role of soluble TNF in the MIA model of ASD.15.
- Medicine and Medical Research