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Influence of BDNF Genotype and Exercise on BDNF Serum Levels and VO2 Max after Acute Exercise and Post Training

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Technical Report,01 Jul 2011,31 Jul 2016

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Air Force Research Laboratory Wright-Patterson AFB United States

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Exercise has been associated with improvements in attention, memory and metabolic capacity VO2Max. Differential effects of exercise type on these variables have been seen. A large body of evidence suggests better VO2Max is associated with better cognitive function. Brain-derived neurotrophic factor BDNF which exists as two main polymorphisms alleles, has been shown to effect cognitive capacity via exercise stimuli, and modulates response to exercise. This retrospective cohort study investigated BDNF allele association with exercise type. Outcome variables were VO2Max and serum BDNF levels. Preliminary results suggest that BDNF allele type does affect post-training VO2Max and post-acute exercise bout BDNF serum level regardless of high HC or low cognitive exercise training type. Also, two different exercise types produced different VO2Max and post-acute exercise BDNF serum levels regardless of allele. Each allele type has been associated with variable effects on memory and attention. Further study is necessary to fully characterize BDNF allele effects by exercise type on Airman cognitive and physiological outcomes to facilitate precision exercise prescription and training.

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  • Anatomy and Physiology

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