Low-Cost, High-Throughput 3D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low-Field MRI
Technical Report,30 Sep 2015,29 Sep 2016
Vanderbilt University Medical Center Nashville United States
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According to the original statement of work we have focused our activities on three specific aims. With regards to Aim number 1, we have completed the design and prototyping of 129Xe automated hyperpolarizer and began polarizer prototypefinal design construction and testing With regards to Aim number 2, we have focused a considerable amount of time on investigating the fundamental parameters of propane hyperpolarization and lifetimes in the gas and liquid phase. In particular, we have studied the pressure dependence of the propane lifetimes and high and low magnetic fields. We also discovered that propane lifetime can be significantly extended in the liquid state. Moreover, we also investigated both approaches homogeneous and heterogeneous hydrogenation in the context of propane hyperpolarization and demonstrated that up to 9 percent polarization can be achieved an order of magnitude improvement vs. preliminary results. These discoveries guided our efforts for the overall propane hyperpolarizer design. Regarding aim number 3, we have worked with equipment vendors and finalized the design of thelow-field MRI scanner. We also note that we are submitting a duplicating report for two partnering PI awards of the same project W81XWH-15-1-0271 and W81XWH-15-1-0272.
- Medicine and Medical Research