Accession Number:

AD1046566

Title:

Cell Based Meniscal Repair Using an Aligned Bioactive Nanofibrous Sheath

Descriptive Note:

Technical Report,15 Jun 2016,14 Jun 2017

Corporate Author:

University of Pittsburgh Pittsburgh United States

Personal Author(s):

• Rothrauff, Benjamin
• Tuan,Rocky

Report Date:

2017-07-01

Pagination or Media Count:

28.0

Abstract:

The goal of this proposal is to develop a novel bio-activated, aligned, nanofibrous scaffold that will serve as mechanical and biological support for the repair of radial tears of the meniscus. The hypothesis is that scaffolds consisting of aligned polymeric fibers, which structurally and mechanically mimic tendon and fibrocartilage, may be applied as a patch in alignment with the fibers of the tissue to be repaired, i.e., the meniscus with radial tear, to strengthen mechanically the surgical meniscal repair, and to subsequently guide tissue regeneration, for example, by seeded tissue progenitor cells.

Descriptors:

• tissue engineering
• stem cells
• regenerative medicine
• polymers
• fibers
• repair
• SHEATHS (ANATOMY)

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE